BMPR1B Antibody
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
O00238
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 134-162 from the human protein was used as the immunogen for this BMPR1B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the BMPR1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This BMPR1B antibody is available for research use only.
Storage Conditions
Aliquot the BMPR1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membrane
Image Legend
BMPR1B antibody western blot analysis in U251 lysate. Predicted molecular weight 55~60 kDa.
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