TGFBR2 Antibody
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000, IHC (Paraffin) : 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
P37173
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 13-40 from the human protein was used as the immunogen for this TGFBR2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TGFBR2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TGFBR2 antibody is available for research use only.
Storage Conditions
Aliquot the TGFBR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TGFBR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
TGFBR2 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue.
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