DLK Antibody
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14) . This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P80370
Host
Rabbit
Reactivity
Human
Immunogen
This DLK antibody was produced from rabbits immunized with a recombinant protein of human DLK.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the DLK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DLK antibody is available for research use only.
Storage Conditions
Aliquot the DLK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the DLK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
DLK antibody western blot analysis in CEM lysate. Observed molecular weight 41~60 kDa depending on glycosylation level.
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