CDKN2C Antibody
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P42773
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 113-139 from the human protein was used as the immunogen for this CDKN2C antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CDKN2C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CDKN2C antibody is available for research use only.
Storage Conditions
Aliquot the CDKN2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CDKN2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of CDKN2C antibody and 293 cell lysate either nontransfected (Lane 1) or transiently transfected (2) with the CDKN2C gene.
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