Dnmt3b Antibody
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000, IHC (Paraffin) : 1:10-1:50
UniProt
Q9UBC3
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 389-417 from the human protein was used as the immunogen for this Dnmt3b antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dnmt3b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dnmt3b antibody is available for research use only.
Storage Conditions
Aliquot the Dnmt3b antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Dnmt3b antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Dnmt3b antibody at 1:2000 dilution + T47D lysate; Predicted molecular weight: 95 kDa.
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