Dnmt3a Antibody
Dnmt3a is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt]
Product Specifications
UniProt
Q9Y6K1
Host
Rabbit
Immunogen
A portion of amino acids 457-486 from the human protein was used as the immunogen for this Dnmt3a antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dnmt3a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dnmt3a antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6679148/datasheet/f40603-0.4ml.pdf
CAS Number
9007-83-4
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