TFAM Antibody
This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
UniProt
Q00059
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 216-246 from the human protein was used as the immunogen for this TFAM antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, FACS, IF, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TFAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TFAM antibody is available for research use only.
Storage Conditions
Aliquot the TFAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TFAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot analysis of lysate from (1) HeLa, (2) HepG2 and (3) U-2OS cell line using TFAM antibody at 1:1000. Expected molecular weight: 24~29 kDa.
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