AMACR Antibody
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
Q9UHK6
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 323-351 from the human protein was used as the immunogen for this AMACR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IF, WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the AMACR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AMACR antibody is available for research use only.
Storage Conditions
Aliquot the AMACR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the AMACR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
AMACR antibody western blot analysis in MDA-MB-231 lysate. Predicted molecular weight ~43 kDa.
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