CYP1A1 Antibody
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:1000
UniProt
P04798
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 377-405 from the human protein was used as the immunogen for this CYP1A1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
655CT6.1.2
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CYP1A1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CYP1A1 antibody is available for research use only.
Storage Conditions
Aliquot the CYP1A1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CYP1A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate
Location
Cytoplasmic, membrane
Image Legend
CYP1A1 antibody western blot analysis in Jurkat lysate. Predicted molecular weight ~58kDa.
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