LOX Antibody / Lysyl Oxidase

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I) . Two transcript variants encoding different isoforms have been found for this gene.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:100-1:500

UniProt

P28300

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 234-260 from the human protein was used as the immunogen for this LOX antibody.

Clonality

Monoclonal

Isotype

IgG2b

Clone

624CT23.7.3

Applications

WB, ELISA

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the LOX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This LOX antibody is available for research use only.

Storage Conditions

Aliquot the LOX antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the LOX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Mouse, Rat, Pig

Image Legend

LOX antibody western blot analysis in MDA-MB231 lysate. Expected molecular weight: ~47 kDa (unprocessed/unmodified), ~50 kDa (glycosylated), ~32 kDa (processed form) .