IGHD Antibody
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:250
UniProt
P01880
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 37-64 from the human protein was used as the immunogen for this IGHD antibody.
Clonality
Monoclonal
Isotype
IgM
Clone
607CT8.4.4
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the IGHD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IGHD antibody is available for research use only.
Storage Conditions
Aliquot the IGHD antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the IGHD antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IGHD antibody western blot analysis in CEM lysate.
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