Integrin beta 2 Antibody
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1) . Two transcript variants encoding the same protein have been identified for this gene.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:25, Western blot: 1:100-1:1000
UniProt
P05107
Host
Mouse
Reactivity
Human
Immunogen
Purified His-tagged protein fragment was used to produced this monoclonal Integrin beta 2/CD18 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
534CT6.2.1
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Integrin beta 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Integrin beta 2 antibody is available for research use only.
Storage Conditions
Aliquot the Integrin beta 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Integrin beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Immunohistochemical analysis of paraffin-embedded human tonsil using Integrin beta 2 antibody at 1:25 dilution.
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