MMP14 Antibody
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:1000, Immunofluorescence: 1:10-1:50
UniProt
P50281
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 470-499 from the human protein was used as the immunogen for this MMP14 antibody.
Clonality
Monoclonal
Isotype
IgM
Clone
133CT15.10.5.1
Applications
WB, IF, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MMP14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MMP14 antibody is available for research use only.
Storage Conditions
Aliquot the MMP14 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MMP14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Mouse, Pig, Rabbit, Rat
Image Legend
Western blot testing of MMP14 antibody at 1:1000 dilution + HT-1080 lysate; Predicted molecular weight: ~66/54kDa.
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