TPX2 Antibody / p100
TPX2/p100 is a spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:1000
UniProt
Q9ULW0
Host
Mouse
Reactivity
Human, Mouse
Immunogen
A KLH conjugated synthetic peptide from the human protein was used as immunogen for this TPX2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
19AT953.286.93
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the TPX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TPX2 antibody is available for research use only.
Storage Conditions
Aliquot the TPX2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TPX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from HT29, Jurkat, MCF-7 cell line (left to right) using TPX2 antibody
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