SPHK1 Antibody
SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.
Product Specifications
UniProt
Q9NYA1
Host
Rabbit
Immunogen
A portion of amino acids 313-343 from the human protein was used as the immunogen for this SPHK1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the SPHK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SPHK1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6678767/datasheet/f40149-0.4ml.pdf
CAS Number
9007-83-4
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