PKM2 Antibody
PKM2 is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:200, Western blot: 1:1000, IHC (Paraffin) : 1:50-1:1:100
UniProt
P14618
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 476-505 from the human protein was used as the immunogen for this PKM2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the PKM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PKM2 antibody is available for research use only.
Storage Conditions
Aliquot the PKM2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/pkm2-antibody-f40140
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PKM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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