LATS2 Antibody
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. This protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
Q9NRM7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 228-258 from the human protein was used as the immunogen for this LATS2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LATS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LATS2 antibody is available for research use only.
Storage Conditions
Aliquot the LATS2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the LATS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
LATS2 antibody used in western blot to detect LATS2 in NIH3T3 cell lysate
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