DSCR1 Antibody

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

P53805

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 222-252 from the human protein was used as the immunogen for this DSCR1 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the DSCR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This DSCR1 antibody is available for research use only.

Storage Conditions

Aliquot the DSCR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the DSCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Bovine, Hamster, Mouse, Rat

Image Legend

Endothelial cell lysate transferred to membrane was incubated with DSCR1 antibody at a 1:500 dilution. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor.