SYVN1 Antibody (HRD1)
HRD1/SYVN1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of SYVN1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. It is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:200-1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q86TM6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 586-617 from the human protein was used as the immunogen for this SYVN1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the SYVN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SYVN1 antibody is available for research use only.
Storage Conditions
Aliquot the SYVN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the SYVN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Frequently Asked Questions
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