NUP50 Antibody
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. NUP50 may serve as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes. It interacts with multiple transport receptor proteins including p27Kip1. This interaction is required for correct intracellular transport and degradation of p27Kip1.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9UKX7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 432-461 from the human protein was used as the immunogen for this NUP50 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the NUP50 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NUP50 antibody is available for research use only.
Storage Conditions
Aliquot the NUP50 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NUP50 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Rat
Image Legend
Frequently Asked Questions
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