GAK Antibody
GAK, a member of the Ser/Thr protein kinase family, associates with cyclin G and CDK5. It appears to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. GAK localizes to the perinuclear area and to the trans-Golgi network. It is also observed on the plasma membrane, probably at focals adhesions. Expression is ubiquitous, wiht highest levels in testis. The protein contains 1 J domain and 1 tensin domain.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Western blot: 1:100-1:1000
UniProt
Q6P490
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 15-45 from the human protein was used as the immunogen for this GAK antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the GAK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GAK antibody is available for research use only.
Storage Conditions
Aliquot the GAK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the GAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC analysis of FFPE human hepatocarcinoma stained with the GAK antibody
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