Sulfamethoxazole (sodium)

Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].

Product Specifications

CAS Number

[4563-84-2]

Product Name Alternative

Ro 4-2130 (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sulfamethoxazole-sodium.html

Concentration

10mM

Purity

99.45

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 100 mg/mL

Smiles

O=S(C1=CC=C(N)C=C1)([N-]C2=NOC(C)=C2)=O.[Na+]

Molecular Formula

C10H10N3NaO3S

Molecular Weight

275.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Zambuzzi-Carvalho et al. Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole. Med Mycol. 2015;53 (5) :477-492. |[2]Choonara BF, et al. A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix. AAPS PharmSciTech. 2015 Aug;16 (4) :771-86.|[3]Ogata H, et al. Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose Response. 2023 Sep 28;21 (3) :15593258231203611.