Citrullinated GRP78 Human Recombinant

<strong>Citrullinated GRP78 Human Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2018748_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 74.6 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> BiP, Endoplasmic Reticulum Lumenal Ca2+-Binding Protein GRP78, Glucose-Related Protein 78, Heat Shock Protein 5 (70 kDa), Hsp5 (70 kDa), Immunoglobulin Heavy Chain-Binding Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Azoury ME, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaut A, Giraud M, Irla M, Lalanne AI, Carré A, Afonso G, Zhou Z, Brandao B, Colli ML, Sebastiani G, Dotta F, Nakayama M, Eizirik DL, You S, Pinto S, Mamula MJ, Verdier Y, Vinh J, Buus S, Mathieu C, Overbergh L, Mallone R. CD8(+) T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes Diabetes. 2021 Dec;70(12):2879-2891._x000D_ 2: Brentville VA, Symonds P, Chua J, Skinner A, Daniels I, Cook KW, Koncarevic S, Martinez-Pinna R, Shah S, Choudhury RH, Vaghela P, Weston D, Al-Omari A, Davis J, Durrant LG. Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy Front Immunol. 2022 Dec 5;13:1066185._x000D_ 3: Lu MC, Lai NS, Yu HC, Huang HB, Hsieh SC, Yu CL. Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production Arthritis Rheum. 2010 May;62(5):1213-23._x000D_ 4: Gonzalez-Gronow M, Pizzo SV. Physiological Roles of the Autoantibodies to the 78-Kilodalton Glucose-Regulated Protein (GRP78) in Cancer and Autoimmune Diseases Biomedicines. 2022 May 24;10(6):1222._x000D_ 5: Lu MC, Lai NS, Yin WY, Yu HC, Huang HB, Tung CH, Huang KY, Yu CL. Anti-citrullinated protein antibodies activated ERK1/2 and JNK mitogen-activated protein kinases via binding to surface-expressed citrullinated GRP78 on mononuclear cells J Clin Immunol. 2013 Apr;33(3):558-66._x000D_ 6: Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L. Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes Diabetes. 2018 Nov;67(11):2337-2348._x000D_ 7: Rondas D, Crèvecoeur I, D'Hertog W, Ferreira GB, Staes A, Garg AD, Eizirik DL, Agostinis P, Gevaert K, Overbergh L, Mathieu C. Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes Diabetes. 2015 Feb;64(2):573-86._x000D_ 8: Chi H, Hao W, Qi X, Zhang T, Dong Y, Gao H, Wei C, Shi W. A proteomic approach towards understanding the pathogenesis of Mooren's ulcer Exp Eye Res. 2021 Apr;205:108509._x000D_ 9: Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, Yamamoto K. Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis Arthritis Res Ther. 2011;13(6):R191._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/27618024">10: Yu HC, Lai PH, Lai NS, Huang HB, Koo M, Lu MC. Increased Serum Levels of Anti-Carbamylated 78-kDa Glucose-Regulated Protein Antibody in Patients with Rheumatoid Arthritis Int J Mol Sci. 2016 Sep 8;17(9):1510. </a>_x000D_ _x000D_ <strong>Products Related to Citrullinated GRP78 Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>