Cannflavin A

Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC50 = 29.4 μM) . Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line[1][2][3][4].

Product Specifications

CAS Number

[76735-57-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Apoptosis; KMO

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cannflavin-a.html

Purity

99.20

Solubility

10 mM in DMSO|DMSO : ≥ 30mg/mL

Smiles

OC1=C2C(OC(C3=CC(OC)=C(C=C3)O)=CC2=O)=CC(O)=C1C/C=C(C)/CC/C=C(C)\C

Molecular Formula

C26H28O6

Molecular Weight

436.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Rea KA, et al. Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry. 2019 Aug;164:162-171.|[2]Eggers C, et al. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone. Biochem Pharmacol. 2019 Nov;169:113609.|[3]Puopolo T, et al. Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase. Biology (Basel) . 2022 Sep 28;11 (10) :1416.|[4]Tomko AM, et al. Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer. J Cannabis Res. 2022 Jul 22;4 (1) :41.