Tubulin degrader 1
Tubulin degrader 1 (Compound 5i) is a BML284 derivative that is an orally active colchicine-site noncovalent tubulin degradation agent with IC50 values ranging from 0.02 to 0.05 μM against the five tumor cell lines (Hela, HCT116, MCF-7, K562 and Molm-13). Tubulin degrader 1 has antiproliferative activity that effectively suppressed tumor growth[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-degrader-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC(C2=CC(NCC3=CC4=C(NC=C4)C=C3)=NC(N)=N2)=C1
Molecular Formula
C20H19N5O
Molecular Weight
345.40
References & Citations
[1]Zhang C, et al. Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur J Med Chem. 2024 Feb 27;268:116265.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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