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Anti-DcR3 (NT) Antibody

Rabbit Polyclonal Antibody specific to DcR3 (NT)

Product Specifications

Product Name Alternative

Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68

Gene Name

TNFRSF6B

Gene ID

8771

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFRSF6B">TNFRSF6B</a>

UniProt

O95407

Accession Number

NP_003814

Cellular Locus

Secreted.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 31-46 of human DcR3 precursor (accession no. AF104419).

Target Antigen

Tumor necrosis factor receptor superfamily member 6B

Target

DcR3 (NT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

DPubMed:21300286}.

Additionnal Information

Immunoblotting: use at 1ug/mL. <br><br>These are recommended concentrations. <br><br>Enduser should determine optimal concentrations for their applications. <br><br>Positive control: Human heart tissue lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/2140.pdf

Specificity

This antibody recognizes human, mouse, and rat DcR3 (33kDa).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane- associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL- and LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues.

CAS Number

9007-83-4

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