Phospho-MEK1/2 (Ser221) Rabbit APC Conjugate

<strong>Phospho-MEK1/2 (Ser221) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018865_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Dual specificity mitogen-activated protein kinase kinase 1/2, MAPK/ERK kinase 1, MAPKK1, MAPKK2, MAP2K1, MAP2K2, PRKMK1, PRKMK2_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Guo Y, Kamara S, Zhang J, Wen H, Zheng M, Liu Y, Zhou L, Chen J, Zhu S, Zhang L. EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models Front Cell Infect Microbiol. 2023 Jan 4;12:1078504._x000D_ 2: Fu DT, Tu J, Cai YQ, Cai ZW, Zhang LZ, Liu JY, Xu SC, Wang DJ. [The regulatory mechanism of Raf/MEK/ERK pathway on the rat cardiac hypertrophy induced by transverse aortic constriction] Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Jan 28;36(1):33-38._x000D_ 3: Aye IL, Jansson T, Powell TL. Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts Mol Cell Endocrinol. 2013 Dec 5;381(1-2):46-55._x000D_ 4: Deacon K, Blank JL. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo J Biol Chem. 1997 May 30;272(22):14489-96._x000D_ 5: Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation J Biol Chem. 2003 Apr 18;278(16):14087-91._x000D_ 6: Abi-Habib RJ, Urieto JO, Liu S, Leppla SH, Duesbery NS, Frankel AE. BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin Mol Cancer Ther. 2005 Sep;4(9):1303-10._x000D_ 7: Zhang JX, Zhuang WJ, Poon KH, Yang M, Fong WF. Induction of HL-60 cell differentiation by the p38 mitogen-activated protein kinase inhibitor SB203580 is mediated through the extracellular signal-regulated kinase signaling pathway Anticancer Drugs. 2003 Jan;14(1):31-8._x000D_ 8: Ning L, Kunnimalaiyaan M, Chen H. Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway Surgery. 2008 Dec;144(6):920-4; discussion 924-5._x000D_ 9: King ML, Murphy LL. American ginseng (Panax quinquefolius L.) extract alters mitogen-activated protein kinase cell signaling and inhibits proliferation of MCF-7 cells J Exp Ther Oncol. 2007;6(2):147-55._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/21321384">10: Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget. 2010 Dec;1(8):751-756. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-MEK1/2 (Ser221) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>