Etelcalcetide (hydrochloride)
Product Specifications
UNSPSC Description
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].
Target Antigen
CaSR
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/etelcalcetide-hydrochloride.html
Purity
99.61
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@H](NC(C)=O)CSSC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=O.[H]Cl.[17/2]
Molecular Weight
1353.33
References & Citations
[1]Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1|[2]Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39(3):396-403.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1955A/Etelcalcetide-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1955A/Etelcalcetide-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1334237-71-6
Available Sizes
Curated Selection
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