Etelcalcetide (hydrochloride)

Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR) . Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].

Product Specifications

CAS Number

[1334237-71-6]

Product Name Alternative

Velcalcetide (hydrochloride) ; AMG 416 (hydrochloride) ; KAI-4169 (hydrochloride)

UNSPSC

12352209

Hazard Statement

H302

Target

CaSR

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/etelcalcetide-hydrochloride.html

Purity

99.80

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@H](NC(C)=O)CSSC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=O.[H]Cl.[17/2]

Molecular Formula

C38H73N21O10S2.17/2HCl

Molecular Weight

1353.33

Precautions

H302

References & Citations

[1]Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1|[2]Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39 (3) :396-403.