P53-MDM2-IN-5
P53-MDM2-IN-5 (compound 5a) is a potent p53-MDM2 inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity[1].
Product Specifications
CAS Number
2750075-06-8
UNSPSC
12352005
Target
Apoptosis; Autophagy; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p53-mdm2-in-5.html
Smiles
N#C[C@@]1(C2=C(C=C(C=C2)Cl)F)[C@@H](C3=C(C(Cl)=CC=C3)F)[C@@H](N[C@H]1CC(C)(C)C)C(NC4=C(C=C(C=C4)C([O-][Pt+4]([Cl-])([Cl-])([NH3])([NH3])[O-]C(C)=O)=O)OC)=O
Molecular Formula
C33H37Cl4F2N5O6Pt
Molecular Weight
974.57
References & Citations
[1]Liu W, et al. Discovery of Novel p53-MDM2 Inhibitor (RG7388) -Conjugated PlatinumIV Complexes as Potent Antitumor Agents. J Med Chem. 2024 Jun 13;67 (11) :9645-9661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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