TopBP1-IN-1
TopBP1-IN-1 is a TopBP1 inhibitor. TopBP1-IN-1 has a synergistic effect with PARP inhibitors. TopBP1-IN-1 has antitumor activity [1].
Product Specifications
CAS Number
[1212595-23-7]
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topbp1-in-1.html
Purity
98.35
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1C([C@@H]2[C@]3([H])C[C@@H](N(CC3)C2)CNCC4=CC=C(C=C4)OC)=CC(C5=CC6=C(C=CC=C6)C=C5)=N1
Molecular Formula
C30H34N4O
Molecular Weight
466.62
References & Citations
[1]Lin FT, et al. A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors. Proc Natl Acad Sci U S A. 2023 Oct 31;120 (44) :e2307793120.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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