TopBP1-IN-1
Product Specifications
UNSPSC Description
TopBP1-IN-1 is a TopBP1 inhibitor. TopBP1-IN-1 has a synergistic effect with PARP inhibitors. TopBP1-IN-1 has antitumor activity [1].
Target Antigen
Others; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topbp1-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1C([C@@H]2[C@]3([H])C[C@@H](N(CC3)C2)CNCC4=CC=C(C=C4)OC)=CC(C5=CC6=C(C=CC=C6)C=C5)=N1
Molecular Weight
466.62
References & Citations
[1]Lin FT, et al. A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2307793120.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160409/TopBP1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160409/TopBP1-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1212595-23-7
Available Sizes
Curated Selection
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