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Ceftiofur (Standard)

Ceftiofur (Standard) is the analytical standard of Ceftiofur. This product is intended for research and analytical applications. Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].

Product Specifications

CAS Number

80370-57-6

UNSPSC

12352005

Target

Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; Reference Standards; TNF Receptor

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ceftiofur-standard.html

Smiles

O=C(C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O

Molecular Formula

C19H17N5O7S3

Molecular Weight

523.56

References & Citations

[1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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