Antibacterial agent 256

Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I) . Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model[1].

Product Specifications

CAS Number

[3052804-28-8]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-256.html

Smiles

CC(C1)C/C(C2=C1C(C(O)=O)=C(C=CC=C3)C3=N2)=C\C4=CC=C(C5=CC=C(Cl)C(C(F)(F)F)=C5)S4

Molecular Formula

C27H19ClF3NO2S

Molecular Weight

513.96

References & Citations

[1]Lu X, et al., Discovery and optimization of tetrahydroacridine derivatives as a novel class of antibiotics against multidrug-resistant Gram-positive pathogens by targeting type I signal peptidase and disrupting bacterial membrane. Eur J Med Chem. 2024 Nov 26;283:117101.