SU1498

SU1498 (AG 1498) is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC50 of value of 700 nM[1].

Product Specifications

CAS Number

[168835-82-3]

Product Name Alternative

AG 1498; Tyrphostin SU 1498

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SU1498.html

Purity

98.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC(C(C)C)=C(O)C(C(C)C)=C2

Molecular Formula

C25H30N2O2

Molecular Weight

390.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Strawn LM, et al. Flk-1 as a target for tumor growth inhibition.Cancer Res. 1996 Aug 1;56 (15) :3540-5.|[2]Boguslawski G, et al. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro.J Biol Chem. 2004 Feb 13;279 (7) :5716-24.|[3]Arbiser JL, et al. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo.Am J Pathol. 2000 Apr;156 (4) :1469-76.|[4]Mesti T, et al. Metabolic impact of anti-angiogenic agents on U87 glioma cells.PLoS One. 2014 Jun 12;9 (6) :e99198.