Dyrk1A-IN-11
Dyrk1A-IN-11 (compound 166) is a potent dual-specificity tyrosine phosphorylation- regulated 1A (DYRK1A) inhibitor with an EC50 value of 0.0021 µM. Dyrk1A-IN-11 inhibits the Phospho-Tau (Thr212) with an EC50 value of 0.0361 µM[1].
Product Specifications
CAS Number
[3058626-26-6]
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-11.html
Smiles
CC1=NC2=C(N1CC(F)F)N=C(C3=C4N(N=C(N[C@@H]5CCN(C6COC6)CC5(F)F)N=C4)C=C3F)C=C2
Molecular Formula
C23H23F5N8O
Molecular Weight
522.47
References & Citations
[1]Gopi Kumar Mittapalli, et al. Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof. French, WO2024211797A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
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