Dyrk1A-IN-11

Dyrk1A-IN-11 (compound 166) is a potent dual-specificity tyrosine phosphorylation- regulated 1A (DYRK1A) inhibitor with an EC50 value of 0.0021 µM. Dyrk1A-IN-11 inhibits the Phospho-Tau (Thr212) with an EC50 value of 0.0361 µM[1].

Product Specifications

CAS Number

[3058626-26-6]

UNSPSC

12352005

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dyrk1a-in-11.html

Smiles

CC1=NC2=C(N1CC(F)F)N=C(C3=C4N(N=C(N[C@@H]5CCN(C6COC6)CC5(F)F)N=C4)C=C3F)C=C2

Molecular Formula

C23H23F5N8O

Molecular Weight

522.47

References & Citations

[1]Gopi Kumar Mittapalli, et al. Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof. French, WO2024211797A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

DYRK1

Curated Selection

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