SB 415286

SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.

Product Specifications

CAS Number

[264218-23-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; GSK-3

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sb-415286.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(NC1=CC=C(O)C(Cl)=C1)=C2C3=CC=CC=C3[N+]([O-])=O)NC2=O

Molecular Formula

C16H10ClN3O5

Molecular Weight

359.72

Precautions

H315, H319, H335

References & Citations

[1]Coghlan MP, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol. 2000 Oct;7 (10) :793-803.|[2]Pizarro JG, et al. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci. 2008 May-Jun;26 (3-4) :269-76.|[3]MacAulay K, et al. Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. Eur J Biochem. 2003 Sep;270 (18) :3829-38.