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Human STEAP1 Full Length Protein, Twin-Strep, His Tag (Detergent) (SPR verified)

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron (III) . Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target.

Product Specifications

Background

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron (III) . Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target.

Specifications

This protein carries a twin strep tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.7 kDa. The protein migrates as 40-42 kDa and 80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to Glycosylation.

Accession Number

Q9UHE8-1

Expression Region

Glu 2 - Leu 339

Host

HEK293

Target

STEAP1

Conjugation

Unconjugated

Tag

N-Twin-Strep & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

85%

Bioactivity

Immobilized Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Cat. No. ST1-H5283) at 5 μg/mL (100 μL/well) can bind Vandortuzumab biosimilar with a linear range of 0.004-0.25 μg/mL (QC tested).

Format

Liquid

Buffer

50 mM HEPES, 150 mM NaCl, Buffer A, pH7.5

Additives

Glycerol

Molecular Weight

44.7 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

Dry ice

Storage Conditions

-70°C

Package Size

500ug*1

Host or Source

HEK293

Species

Human

Protein ID

Q9UHE8-1

Preservative

Glycerol

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