AC-430 (hydrobromide)
AC-430 hydrobromide (example 1) is a potent JAK2 inhibitor. AC-430 hydrobromide can be used for the research of myeloproliferative disorders and cancer[1].
Product Specifications
CAS Number
[1359828-49-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac-430-hydrobromide.html
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C(C2=NC(NC3=NNC(C)=C3)=C4C=CC=CC4=N2)O)C=C1.Br
Molecular Formula
C19H17BrFN5O
Molecular Weight
430.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Holladay MW, et al. Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof. US20120053193A1. 2012-03-01.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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