DCE-2
DCE-2 (compound 5) is a PROTAC targeting CREB binding protein (CBP) and E1A-associated protein (EP300), which was developed based on the crystal structure of bromodomain (BRD) inhibitors. dCE-2 is composed of E3 ubiquitin ligase ligand Thalidomide-4-OH (HY-103596) (blue part), PROTAC Linker tert-Butyl 11-aminoundecanoate (HY-130715) (black part) and PROTAC target protein ligand EP300/CBP ligand 2 (HY-161960) (red part), of which the target protein ligand activity control is EP300/CBP ligand 1 (HY-161959), and the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C10-Boc (HY-161961) [1].
Product Specifications
UNSPSC
12352005
Target
Histone Acetyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dce-2.html
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCCCCCCCCCC(NC4=CC(C5=NN(C)C=C5)=CC(C(NC6=CC=CC7=C6C=C(C)N=N7)=O)=C4)=O)=C3C1=O
Molecular Formula
C44H47N9O6
Molecular Weight
797.90
References & Citations
[1]Cheng-Sánchez I, et al. Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity. JACS Au. 2024 Aug 8;4 (9) :3466-3474.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161958/dCE-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161958/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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