SLM6
SLM6 is a sangivamycin-like molecule. SLM6 is a CDK9 inhibitor. SLM6 inhibits CDK9/cyclin K and CDK9/cyclin T1 kinase activity with IC50s of 280 nM and 133 nM, respectively. SLM6 also inhibits CDK1/cyclin B and CDK2/ cyclin A with IC50s of less than 300 nM. SLM6 induces apoptosis in multiple myeloma (MM) cells[1].
Product Specifications
CAS Number
22242-91-7
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/slm6.html
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C(C(NN)=N)C3=C(N)N=CN=C32)O1
Molecular Formula
C12H17N7O4
Molecular Weight
323.31
References & Citations
[1]Villanueva-Gutierrez EE, et al. Simple Sequence Repeat Markers Reveal Genetic Diversity and Population Structure of Bolivian Wild and Cultivated Tomatoes (Solanum lycopersicum L.) . Genes (Basel) . 2022 Aug 23;13 (9) :1505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Frequently Asked Questions
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