PROTAC NAMPT Degrader-1
Product Specifications
UNSPSC Description
PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with aDC50 value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC50 value of 0.12μM against A2780 cells.
(Structure Note: PINK, NAMPT activator (HY-163445); Blue, VHL ligand (HY-163440); Black, linker)[1].
Target Antigen
NAMPT; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-nampt-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=NC=C1)NC2=CC=C(C=C2)S(=O)(N3CCN(CC3)C(C4=CC=C(C=C4)/N=N/C5=C(N(N=C5C)CCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)=O)=O)C)=O)=O
Molecular Weight
1128.37
References & Citations
[1]Cheng J, et al. Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD. Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202315997.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163440/PROTAC-NAMPT-Degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163440/
Clinical Information
No Development Reported
Curated Selection
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