Flibanserin-d4-1

Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM) . Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD) [1][2].

Product Specifications

CAS Number

[2122830-91-3]

Product Name Alternative

BIMT-17-d4-1; BIMT-17BS-d4-1

UNSPSC

12352005

Target

5-HT Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.28

Solubility

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=CC=CC(N(CC2)CCN2C([2H])([2H])C([2H])([2H])N3C4=CC=CC=C4NC3=O)=C1

Molecular Formula

C20H17D4F3N4O

Molecular Weight

394.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Gelman F, et al. Flibanserin for hypoactive sexual desire disorder: place in therapy. Ther Adv Chronic Dis. 2017 Jan;8 (1) :16-25.|[3]Invernizzi RW, et al. Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT (1A) receptors. Br J Pharmacol. 2003 Aug;139 (7) :1281-8.