Eticlopride
Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent[1].
Product Specifications
CAS Number
84226-12-0
Product Name Alternative
FLB-131
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eticlopride.html
Smiles
O=C(C1=C(C(CC)=CC(Cl)=C1OC)O)NC[C@H]2N(CCC2)CC
Molecular Formula
C17H25ClN2O3
Molecular Weight
340.85
References & Citations
[1]CHRONIC ETICLOPRIDE AND DOPAMINE DENERVATION INDUCE EQUAL NONADDITIVE INCREASES IN STRIATAL D, RECEPTOR DENSITY: AUTORADIOGRAPHIC EVIDENCE AGAINST THE DUAL MECHANISM HYPOTHESI|[2]Chakroborty D, et al. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108 (51) :20730-5. |[3]Baragli A, et al. Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal. 2007 Nov;19 (11) :2304-16. |[4]Brown RW, et al. The effects of eticlopride on Morris water task performance in male and female rats neonatally treated with quinpirole. Psychopharmacology (Berl) . 2005 Jul;180 (2) :234-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
HX25171 96 Tests
SUPER-X PLEX ® Human IL-32 Flow Cytometry Assay - Group 3
Sign In for Pricing
View Details 
