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Eticlopride

Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent[1].

Product Specifications

CAS Number

84226-12-0

Product Name Alternative

FLB-131

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eticlopride.html

Smiles

O=C(C1=C(C(CC)=CC(Cl)=C1OC)O)NC[C@H]2N(CCC2)CC

Molecular Formula

C17H25ClN2O3

Molecular Weight

340.85

References & Citations

[1]CHRONIC ETICLOPRIDE AND DOPAMINE DENERVATION INDUCE EQUAL NONADDITIVE INCREASES IN STRIATAL D, RECEPTOR DENSITY: AUTORADIOGRAPHIC EVIDENCE AGAINST THE DUAL MECHANISM HYPOTHESI|[2]Chakroborty D, et al. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108 (51) :20730-5. |[3]Baragli A, et al. Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal. 2007 Nov;19 (11) :2304-16. |[4]Brown RW, et al. The effects of eticlopride on Morris water task performance in male and female rats neonatally treated with quinpirole. Psychopharmacology (Berl) . 2005 Jul;180 (2) :234-40.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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