Kemptide (Highly Pure)

<strong>Kemptide (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2012753_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 771.9 g/mol_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> L-leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucyl-glycine_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Araujo NA, Guevara A, Lorenzo MA, Calabokis M, Bubis J. Fluram-Kemptide-Lys8 Non-radioactive Assay for Protein Kinase A Protein J. 2016 Aug;35(4):247-55._x000D_ 2: Kübler D, Pyerin W, Bill O, Hotz A, Sonka J, Kinzel V. Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode J Biol Chem. 1989 Aug 25;264(24):14549-55._x000D_ 3: Giembycz MA, Diamond J. Evaluation of kemptide, a synthetic serine-containing heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues Biochem Pharmacol. 1990 Jan 15;39(2):271-83._x000D_ 4: Hengel SM, Shaffer SA, Nunn BL, Goodlett DR. Tandem mass spectrometry investigation of ADP-ribosylated kemptide J Am Soc Mass Spectrom. 2009 Mar;20(3):477-83._x000D_ 5: Pérez-Gallegos A, Garcia-Viloca M, González-Lafont À, Lluch JM. A QM/MM study of Kemptide phosphorylation catalyzed by protein kinase A. The role of Asp166 as a general acid/base catalyst Phys Chem Chem Phys. 2015 Feb 7;17(5):3497-511._x000D_ 6: Lee CS, Oh DE, Kim TH. Label-free assay of protein kinase A activity and inhibition in cancer cell using electrochemically-prepared AuNP/rGO nanohybrid electrode modified with C-Kemptide Talanta. 2020 Aug 1;215:120899._x000D_ 7: Montenegro M, Garcia-Viloca M, Lluch JM, González-Lafont A. A QM/MM study of the phosphoryl transfer to the Kemptide substrate catalyzed by protein kinase A. The effect of the phosphorylation state of the protein on the mechanism Phys Chem Chem Phys. 2011 Jan 14;13(2):530-9._x000D_ 8: Klarlund JK, Jaspers SR, Khalaf N, Bradford AP, Miller TB, Czech MP. An insulin-stimulated kemptide_ kinase purified from rat liver is deactivated by phosphatase 2A J Biol Chem. 1991 Mar 5;266(7):4052-5._x000D_ 9: Mena-Ulecia K, Vergara-Jaque A, Poblete H, Tiznado W, Caballero J. Study of the affinity between the protein kinase PKA and peptide substrates derived from kemptide using molecular dynamics simulations and MM/GBSA PLoS One. 2014 Oct 2;9(10):e109639._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29399821">10: Mena-Ulecia K, Gonzalez-Norambuena F, Vergara-Jaque A, Poblete H, Tiznado W, Caballero J. Study of the affinity between the protein kinase PKA and homoarginine-containing peptides derived from kemptide: Free energy perturbation (FEP) calculations J Comput Chem. 2018 Jun 15;39(16):986-992. </a>_x000D_ _x000D_ <strong>Products Related to Kemptide (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Substrates/"> Substrates</a>