Anti-Hu CD160 FITC
CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Human NK cell line YT2C2
Target Antigen
CD160
Clone
BY55
Applications
FC (QC tested)
Format
FITC
Buffer
Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
Applications Notes
6
Isotype
Mouse IgM kappa
Frequently Asked Questions
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