Cephaeline
Cephaeline ((-) -Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy[1][2][3][4].
Product Specifications
CAS Number
483-17-0
Product Name Alternative
(-) -Cephaeline; NSC 32944 (free base)
UNSPSC
12352005
Hazard Statement
H300, H330
Target
Ferroptosis; Filovirus; Flavivirus; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/cephaeline.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 33.33 mg/mL (ultrasonic)
Smiles
OC1=CC2=C([C@@H](C[C@@H]3[C@@H](CC)CN4CCC5=CC(OC)=C(OC)C=C5[C@]4([H])C3)NCC2)C=C1OC
Molecular Formula
C28H38N2O4
Molecular Weight
466.61
Precautions
H300, H330
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
EBOV
Available Sizes
Frequently Asked Questions
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