Antiproliferative agent-61
Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1].
Product Specifications
CAS Number
[1613078-24-2]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-61.html
Smiles
O=C(/C=C/C1=NC=CC2=C1NC3=C2C=CC=C3)C4=CC=C(C(OC)=C4)OC
Molecular Formula
C22H18N2O3
Molecular Weight
358.39
References & Citations
[1]Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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